DocumentCode :
2556923
Title :
PET performance evaluation of a pre-clinical SiPM based MR-compatible PET scanner
Author :
Mackewn, J.E. ; Lerche, C.W. ; Sunassee, Kavitha ; de Rosales, Rafael T. M. ; Phinikaridou, Alkystis ; Salomon, Antoine ; Ayres, Richard ; Tsoumpas, Charalampos ; SouItanidis, Georgios M. ; Schaeffter, Tobias ; Marsden, P.K. ; Schulz, V.
Author_Institution :
Div. of Imaging Sci. & Biomed. Eng., King´s Coll. London, London, UK
fYear :
2012
fDate :
Oct. 27 2012-Nov. 3 2012
Firstpage :
2776
Lastpage :
2779
Abstract :
We have carried out a PET performance evaluation of an SiPM based scanner designed for fully simultaneous preclinical PET/MR studies. The PET scanner has an inner diameter of 20 cm with a crystal size of 1.3 by 1.3 by 10 mm. The crystals are read out using MR-compatible SiPMs to allow the PET scanner to be located within a Philips 3T Achieva MRI scanner. The spatial resolution of the system, measured using SSRB and 2D FBP is just under 2.4mm in the trans-axial and axial directions. The system sensitivity is 0.6% for a point source at the centre of the field of view. The true coincidence count rate shows no sign of saturating at 30 MBq, at which point the randoms fraction is 9%, and the scatter fraction for a rat sized object is approximately 23%. Artefact-free images of phantoms have been obtained using SSRB/FBP and iterative reconstructions. The current performance is limited because only one of three axial ring positions is currently populated with detectors, and limitations of the first-generation detector readout ASIC used in the system. The performance of the system as described is sufficient for imaging rat-sized animals and large organs within the mouse. We have demonstrated here the feasibility of using the system to investigate dynamic processes simultaneously in a mouse using PET and MR with a dual labeled PET/MR probe. Extrapolating from the current performance results we anticipate that population of all three detector rings and upgrading of the readout ASIC will result in an MR-compatible PET scanner with performance similar to that of state-of-the-art non-MR-compatible pre-clinical systems.
Keywords :
application specific integrated circuits; biological organs; biomedical MRI; image reconstruction; image scanners; iterative methods; medical image processing; performance evaluation; phantoms; photomultipliers; positron emission tomography; MR-compatible PET scanner; Philips 3T Achieva; SSRB; SiPM based scanner; YSO/silicon photomultiplier; coincidence count rate; first-generation detector readout ASIC; performance evaluation; size 1.3 mm; size 10 mm; size 20 cm; spatial resolution; system sensitivity;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE
Conference_Location :
Anaheim, CA
ISSN :
1082-3654
Print_ISBN :
978-1-4673-2028-3
Type :
conf
DOI :
10.1109/NSSMIC.2012.6551633
Filename :
6551633
Link To Document :
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