Title :
An acoustic plate mode immunosensor
Author :
Andle, J.C. ; Vetelino, J.F. ; Lec, R. ; McAllister, D.J.
Author_Institution :
Dept. of Electr. Eng., Maine Univ., Orono, ME, USA
Abstract :
The application of an acoustic plate mode (APM) device as an immunosensor is presented. The APM sensor utilizes a Z-cut X-propagating lithium niobate (LiNbO/sub 3/) piezoelectric plate in which various types of acoustic waves are excited and received by means of a photolithographically deposited aluminium interdigital transducer (IDT). A judicious choice of the sensor operating frequency results in the selective excitation of an acoustic mode that is highly sensitive to fluid loading of the LiNbO/sub 3/ surface. This mode is then utilized as the sensing element in the sensor. Experiments have been performed using polyclonal antibodies for which the sensor has shown a strong response to the associated antigen. The biokinetics of the antigen-antibody reaction have also been studied. Experimental data compare favorably with theoretical results predicted by an affinity-purified human immunoglobulin antibody-antigen model. This immunosensor also has potential application in detecting various types of viruses such as AIDS (HIV), herpes simplex, and hepatitis.<>
Keywords :
acoustic transducers; aluminium; bioacoustics; biosensors; lithium compounds; AIDS; Al-LiNbO/sub 3/; Z-cut X-propagating piezoelectric plate; acoustic plate mode immunosensor; affinity-purified human immunoglobulin antibody-antigen model; biokinetics; fluid loading; hepatitis; herpes simplex; interdigital transducer; polyclonal antibodies; sensing element; sensor operating frequency; viruses; Acoustic applications; Acoustic devices; Acoustic sensors; Acoustic transducers; Acoustic waves; Aluminum; Biosensors; Immune system; Lithium niobate; Piezoelectric transducers;
Conference_Titel :
Solid-State Sensor and Actuator Workshop, 1990. 4th Technical Digest., IEEE
Conference_Location :
Hilton Head Island, SC, USA
DOI :
10.1109/SOLSEN.1990.109826
