Title :
Fabrication and in vitro testing of porous silicon microcarriers
Author :
Bragaru, A. ; Kusko, M. ; Simion, M. ; Iordanescu, A. ; Pascu, R. ; Danila, B.M. ; Craciunoiu, F. ; Diaconu, M.
Author_Institution :
IMT Bucharest, Bucharest, Romania
Abstract :
Porous materials have been used over a decade in tissue engineering and drug delivery. The aim of this study was to prepare porous silicon microparticles with suitable dimensions for using as drug microcarriers. Two types of anticancer drugs, dacarbazine and bleomycine, have been loaded into these systems for in vitro drug release tests carried out by high pressure liquid chromatography (HPLC) method.
Keywords :
biochemistry; biomedical materials; cancer; chromatography; drug delivery systems; drugs; microfabrication; molecular biophysics; organic compounds; porous materials; silicon; tissue engineering; HPLC method; Si; anticancer drugs; bleomycine; dacarbazine; drug delivery; drug microcarriers; drug release tests; high pressure liquid chromatography; microfabrication; porous materials; porous silicon microcarriers; tissue engineering; Drug delivery; Drugs; In vitro; Iron; Loading; Magnetic resonance imaging; Silicon; PS microcarriers; SPION; therapeutical agents;
Conference_Titel :
Semiconductor Conference (CAS), 2011 International
Conference_Location :
Sinaia
Print_ISBN :
978-1-61284-173-1
DOI :
10.1109/SMICND.2011.6095730
