Analysis on Time-lagged Gene Clusters in Time Series Gene Expression Data

There are a number of previous approaches for identifying time-lagged gene co-regulations. Popularly used cross-correlation method and edge detection method don´t consider the direction of regulation of gene pairs. And event method is proposed to deal with some of the above-mentioned limitations however its scoring system to identify promising time-lagged gene pairs is still questionable. This paper further analyses the time-lagged gene clusters mining process and some probably existing deduced direction of co-regulation ´ s contradictory phenomenon in these clusters/bi- clusters. Besides, the time-lagged value is proposed as a possible prevention mechanism.