Title :
A 24x16 CMOS-Based Chronocoulometric DNA Microarray
Author :
Augustyniak, Marcin ; Paulus, Christian ; Brederlow, Ralf ; Persike, Norbert ; Hartwich, Gerhard ; Schmitt-Landsiedel, Doris ; Thewes, Roland
Author_Institution :
Infineon Technol., Munich
Abstract :
An array of 24 times 16 electrochemical sensors for detecting bio-molecules uses gold sensor electrodes added to a 0.5 mum CMOS process. Detection is based on time-resolved measurement of charge (chronocoulometry). A differential measurement technique uses a replica electrode and fast integration to suppress background offset signals
Keywords :
CMOS integrated circuits; DNA; array signal processing; biological techniques; electrochemical sensors; microsensors; molecular biophysics; 0.5 micron; CMOS; biomolecules; chronocoulometric DNA microarray; chronocoulometry; differential measurement; electrochemical sensors; gold sensor electrodes; time resolved measurement; Current measurement; DNA; Electrodes; Feedback; Leakage current; Measurement techniques; Operational amplifiers; Sensor arrays; Switches; Voltage;
Conference_Titel :
Solid-State Circuits Conference, 2006. ISSCC 2006. Digest of Technical Papers. IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
1-4244-0079-1
DOI :
10.1109/ISSCC.2006.1696034
