An ultra-low current mode amplifier aiming at biosensor applications

Author

Zhang, Lei ; Yu, Zhiping ; He, Xiangqing

Author_Institution

Tsinghua Univ., Beijing

fYear

2007

fDate

22-25 Oct. 2007

Firstpage

477

Lastpage

480

Abstract

Recently, along with the booming of research and production of CMOS integrated bio-sensing system (IBS), ultra-low current mode amplifier (UCMA) which servers for biosensor signal pre-amplification implemented in modern CMOS technology is in high demand in areas like ultra-low bio-current analysis and detection, DNA probing and surveying system and etc. In this paper, a novel UCMA module has been presented and verified by SMIC 0.18 mum CMOS process by elaborately considering gain, bandwidth, stability, noise, DC operating point optimization, as well as offset cancellation. Theoretical calculation, HSPICE simulation, and xCalibre post simulation show that the proposed UCMA can stably provide a current gain of 57.6 dB and 3 dB bandwidth of 4.38 MHz with only InA of DC quiescent current, while the input offset current and noise current are less than 22.8 fA and 66.9 fA /radicHz, respectively.

Keywords

CMOS integrated circuits; amplifiers; biosensors; CMOS integrated bio-sensing system; DC operating point optimization; DNA probing; HSPICE simulation; biosensor applications; biosensor signal pre-amplification; frequency 4.38 MHz; offset cancellation; ultra-low bio-current analysis; ultra-low current mode amplifier; xCalibre post simulation; Bandwidth; Biosensors; CMOS process; CMOS technology; DNA; Noise cancellation; Optimized production technology; Production systems; Signal analysis; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

ASIC, 2007. ASICON '07. 7th International Conference on

Conference_Location

Guilin

Print_ISBN

978-1-4244-1132-0

Electronic_ISBN

978-1-4244-1132-0

Type

conf

DOI

10.1109/ICASIC.2007.4415671

Filename

4415671