Closed-loop system for total intravenous anesthesia by simultaneously administering two anesthetic drugs

Author

Zhang, Xu-Sheng ; Roy, Rob J. ; Huang, Johnnie W.

Author_Institution

Dept. of Biomed. Eng., Rensselaer Polytech. Inst., Troy, NY, USA

Volume

6

fYear

1998

fDate

29 Oct-1 Nov 1998

Firstpage

3052

Abstract

Total Intravenous Anesthesia (TIVA) for general anesthesia using Propofol (a hypnotic) and Fentanyl (a narcotic) is a popular technique. When designing computer control of TIVA, the main difficulty is how to determine the infusion rate of two interacting drugs. In this paper, the authors mainly address the simulation results on the interaction model of two drugs, how to use the model to simultaneously control infusion rates and how to incorporate it into an Automatic Anesthesia Management System (AAMS) for TIVA. The paper provides a novel idea regarding how to design closed-loop system for simultaneously administrating two drugs in TIVA

Keywords

biocontrol; closed loop systems; drug delivery systems; surgery; Fentanyl; Propofol; automatic anesthesia management system; closed-loop drug delivery system; computer control; hypnotic; infusion rate determination; narcotic; simultaneous administration; total intravenous anesthesia; two interacting drugs; Active appearance model; Adaptive control; Anesthesia; Anesthetic drugs; Artificial neural networks; Automatic control; Biomedical engineering; Fuzzy logic; Optimal control; Programmable control;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.746135

Filename

746135