A kinetic model of control on secretion in neuroendocrine cells

Author

Shunhui Wei ; Anlian Qu ; Hongxin Wu ; Zhuan Zhou

Author_Institution

Huazhong Univ. of Sci. & Technol., Hubei, China

Volume

6

fYear

1998

fDate

1-1 Nov. 1998

Firstpage

3083

Abstract

Transmitter release is the fundamental mechanism for chemical communication between cells. The releasing of secretory vesicle contents into extracellular space has several kinetic steps, and each step is controlled by free intracellular calcium concentration [Ca/sup 2+/]/sub i/. The releasable vesicles pool has two parts, immediately releasable pool (IRP) and readily releasable pool (RRP), which are respectively distributed within about 30 nm and 300 nm from Ca/sup 2+/ channels. We use membrane capacitance measurement technique to monitor secretory activity, and determine the size of secretory vesicle pools. A corresponding model of secretion can simulate the dynamics of vesicles pools with the control of [Ca/sup 2+/]/sub i/.

Keywords

biochemistry; bioelectric phenomena; biomembrane transport; capacitance; neurophysiology; physiological models; Ca/sup 2+/ channels; extracellular space; free intracellular calcium concentration; immediately releasable pool; kinetic model of control; membrane capacitance; readily releasable pool; releasable vesicles pool; secretion in neuroendocrine cells; secretory vesicle contents; transmitter release; vesicle pool size; Biomembranes; Calcium; Capacitance measurement; Chemicals; Communication system control; Extracellular; Fluids and secretions; Kinetic theory; Monitoring; Transmitters;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong, China

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.746143

Filename

746143