A patient-specific reduced-order model for coronary circulation

We introduce a patient-specific model for coronary circulation, by combining anatomical, hemodynamic and functional information from medical images and other clinical observations. The main components of the coupled model are: a lumped heart model, a reduced-order model for hemodynamics in the arterial vessel tree (both healthy and stenosed), and a physiological model for the microvascular bed. The anatomy of the vessel tree is extracted from Coronary Computed Tomography Angiography (CTA) images, followed by an estimation of the impedance of the distal microvascular network. For the blood flow simulations, three states are modeled: rest, drug-induced hyperemia and intense exercise. The results show an excellent agreement with the literature and provide a model for virtual assessment of the flow and underlying functional measures in healthy and stenosed coronary arteries.