DocumentCode :
2570431
Title :
Computer-aided drug discovery for pathway and genetic diseases
Author :
Aswani, Anil ; Tomlin, Claire
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of California at Berkeley, Berkeley, CA, USA
fYear :
2010
fDate :
15-17 Dec. 2010
Firstpage :
4709
Lastpage :
4714
Abstract :
Selecting drug targets in pathway and genetic diseases (e.g., cancer) is a difficult problem facing the medical field and pharmaceutical industry. Because of the complex interconnections and feedback found in biological pathways, it is difficult to understand the potential effects of targeting certain portions of the network. The pharmaceutical industry has avoided novel targets for drugs, largely because of the increased risk in developing such treatments. This necessitates the need for systems biology methods which can help mitigate some of the risks of identifying novel targets and also suggest further experiments to validate them. The primary goal of this paper is to introduce a mathematical framework for solving such problems, that is amenable to computational or mathematical study. The secondary goal is to suggest methods for solving problems posed in this framework. One of these methods is a heuristic which is designed to allow its computations to scale up to much bigger examples and pathways than presented here.
Keywords :
diseases; drugs; genetics; medical computing; pharmaceutical industry; biological pathways; complex interconnections; computational study; computer-aided drug discovery; drug target selection; feedback; genetic diseases; mathematical framework; mathematical study; medical field; pathway diseases; pharmaceutical industry; systems biology methods; Biology; Cancer; Diseases; Drugs; Minimization; Optimization;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Decision and Control (CDC), 2010 49th IEEE Conference on
Conference_Location :
Atlanta, GA
ISSN :
0743-1546
Print_ISBN :
978-1-4244-7745-6
Type :
conf
DOI :
10.1109/CDC.2010.5717302
Filename :
5717302
Link To Document :
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