Title :
CMOS Integrated DNA Chip for Quantitative DNA Analysis
Author :
Gemma, Nobuhiro ; O´uchi, S. ; Funaki, Hideyuki ; Okada, Joji ; Hongo, Satoshi
Author_Institution :
Toshiba, Kawasaki
Abstract :
Quantitative gene expression analysis, based on an electrochemical DNA-detection method uses immobilized DNA probes on Au electrodes with diameters from 200mum to 2mum. Cyclic voltammetry is used to measure anodic current from the intercalators. The 25times3mm2 IC, fabricated in 1mum 2M CMOS, contains 40 electrodes, 1600 transistors and dissipates 150mW at plusmn3.3V
Keywords :
CMOS digital integrated circuits; DNA; electrochemical analysis; gold alloys; molecular biophysics; neural chips; 1 micron; 150 mW; 2 to 200 micron; Au; CMOS integrated circuit; DNA chip; anodic current measurement; cyclic voltammetry; electrochemical DNA-detection; intercalators; quantitative DNA analysis; quantitative gene expression; Biochemistry; CMOS technology; Circuits; Current; DNA; Electrodes; Fluorescence; Labeling; Probes; Voltage;
Conference_Titel :
Solid-State Circuits Conference, 2006. ISSCC 2006. Digest of Technical Papers. IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
1-4244-0079-1
DOI :
10.1109/ISSCC.2006.1696291
