A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics

Author

Chen, C.-H. ; Hwang, R.-Z. ; Huang, L.-S. ; Lin, S. ; Chen, H.-C. ; Yang, Y.-C. ; Lin, Y.-T. ; Yu, S.-A. ; Wang, Y.-H. ; Chou, N.-K. ; Lu, S.S.

Author_Institution

Nat. Taiwan Univ., Taipei

fYear

2006

fDate

6-9 Feb. 2006

Firstpage

2298

Lastpage

2307

Abstract

A quick (<30min.), label-free detection of disease-related C-reactive proteins (CRP) is achieved using a 200mum MEMS microcantilever housed in a 7times7mm² reaction chamber. The deflection of the cantilever due to specific CRP/anti-CRP binding is detected using a position-sensitive photodiode and the converted bio-signal is transmitted by a wireless ASK transceiver IC fabricated in a 0.18mum CMOS process. CRP concentrations from 1mug/mL to 500mug/mL can be detected. A 0.2Hz 1V ac signal is applied to the bio-MEMS sensor to unbind CRP from the cantilever for reuse

Keywords

biosensors; cantilevers; microsensors; photodiodes; proteins; 0.18 micron; 0.2 Hz; 1 V; 200 micron; C-reactive protein detection; CMOS process; CRP concentrations; MEMS microcantilever; MEMS sensor; biosensor; biosignal; label-free detection; nanomechanics; position-sensitive photodiode; reaction chamber; wireless ASK transceiver; wireless sensor; Amplitude shift keying; Biosensors; CMOS integrated circuits; CMOS process; Micromechanical devices; Photodiodes; Position sensitive particle detectors; Proteins; Transceivers; Wireless sensor networks;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference, 2006. ISSCC 2006. Digest of Technical Papers. IEEE International

Conference_Location

San Francisco, CA

ISSN

0193-6530

Print_ISBN

1-4244-0079-1

Type

conf

DOI

10.1109/ISSCC.2006.1696292

Filename

1696292