Title :
The effect of retroactivity on the transfer function of a phosphorylation system
Author :
Vecchio, Domitilla Del
Author_Institution :
Dept. of Mech. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA
Abstract :
It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
Keywords :
biochemistry; molecular biophysics; physiological models; transfer functions; biomolecular circuits; impedance-like effects; phosphorylation system; retroactivity; transfer function; Bandwidth; Communication system signaling; Equations; Proteins; Steady-state; Transfer functions;
Conference_Titel :
Decision and Control (CDC), 2010 49th IEEE Conference on
Conference_Location :
Atlanta, GA
Print_ISBN :
978-1-4244-7745-6
DOI :
10.1109/CDC.2010.5717674
