Title :
Gene annotation and network in cancer research
Author_Institution :
Dept. of Life Sci., National Taiwan Univ., Taipei, Taiwan
Abstract :
In this study, we used two high throughput techniques, DNA microarray and proteomics, to survey the global changes in genes and proteins after cyclic RGD peptides treatment on MCF-7 cancer cells. Furthermore, we annotated these gene functions and constructed the gene network using our developed software, BGSSJ and GeneNetwork, respectively. These results provide a molecular explanation for the properties of cRGD in breast cancer cells and put forth a valuable in-depth impact in breast cancer therapy.
Keywords :
DNA; biology computing; cancer; cellular biophysics; genetics; proteins; DNA microarray; GeneNetwork; MCF 7 cancer cell; breast cancer cell; breast cancer therapy; cancer research; cyclic RGD peptides treatment; deoxyribonucleic acid; gene function annotation; gene network; molecular explanation; proteins; proteomics; Bioinformatics; Biology; Breast cancer; Gene expression; Intelligent networks; Java; Peptides; Proteins; Proteomics; Software tools;
Conference_Titel :
Emerging Information Technology Conference, 2005.
Print_ISBN :
0-7803-9328-7
DOI :
10.1109/EITC.2005.1544340
