DocumentCode :
2581832
Title :
Simulations of elastin like proteins
Author :
Olgar, Handan Arkin ; Bilsel, Mustafa
Author_Institution :
Fizik Muhendisligi Bolumu, Ankara Univ., Ankara, Turkey
fYear :
2010
fDate :
21-24 April 2010
Firstpage :
1
Lastpage :
4
Abstract :
(VPGXG)n polypeptides known as elastin-like polypeptides with different biological, biomechanical, biochemical and biophysical properties stand out suitable structures appropriate for production of several biomaterials, in the first instance, tissue, microtube and nanotube in tissue engineering. Therefore, understanding the structural properties of such peptides comes into prominence. For this purpose, structural properties of elastin-like polypeptides have been investigated by computer simulation methods in our study. Our simulations have been carried out by multicanonical algorithm having a wide range of application area from solid state to biophysics, the most powerful algorithm in generalized ensemble family. By taking n=1 and changing aminoacid X, hydrophobicity scale has been established in the forepart of our study, afterwards the effect on structural transition temperature has been determined in a solvent (SCH2) and vacuum. In the second part, choosing VPGVG, the most repeating pentapeptide sequence in elastin-like proteins, and taking n=1, 2, 3, 4, change in structural transition temperature and secondary structure formation caused by the transition from smaller molecule to larger one have been determined.
Keywords :
hydrophobicity; molecular biophysics; proteins; solid-state phase transformations; VPGVG; aminoacid X; computer simulation; elastin like proteins; elastin-like polypeptides; hydrophobicity; multicanonical algorithm; repeatingpentapeptide sequence; secondary structure; structural properties; structural transition temperature; Biological system modeling; Biological tissues; Computational modeling; Computer simulation; Nanobioscience; Peptides; Production; Protein engineering; Temperature; Tissue engineering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering Meeting (BIYOMUT), 2010 15th National
Conference_Location :
Antalya
Print_ISBN :
978-1-4244-6380-0
Type :
conf
DOI :
10.1109/BIYOMUT.2010.5479831
Filename :
5479831
Link To Document :
بازگشت