Maxillary growth following amniotic extracellular matrix graft on mucoperiosteal denudated palate process in rabbits

To observe the growth and devlopment of the maxilla following palatal bone denudation covering with amniotic extracellular matrix (AECM) or palatal mucosal graft in rabbits with surgically created defects simulating palatal bone denudation in rabbits. Methods: 30 New Zealand white rabbits (5 weeks old) were divided into three groups: Group I (left palatal bone denudation was not repaired and the right side was unoperated as a control), Group II (the right side of palatal bone denudation was covered with palatal mucosal graft and the left side was not repaired) and Group HI (the right side of palatal bone denudation was covered with AECM graft and the left side was not repaired). Then the effect of different transplantion on preventing maxillary deformity was investigated and compared. The metric cranial variables were measured directly from the cleaned skulls. Direct cephalometric measurements were taken in the following dimensions: maxillary length, width and height. Results: The length, height and width of the growth of the left maxillary bone was obviously less than that of the right maxillary bone respectively in each group. Maxillary development in the three groups was same and no significant differences among them were discovered. Conclusion: AECM could become the biocompatible material for repairing and preventing maxillary deformity.