Title :
Computer simulation of a mathematical model of HAART therapy for HIV-1 AIDS
Author :
Nani, Frank ; Jin, Mingxian
Author_Institution :
Dept. of Math. & Comput. Sci., Fayetteville State Univ., Fayetteville, NC, USA
Abstract :
A clinically plausible mathematical model is constructed to describe the patho-physiological dynamics of HIV-1 induced AIDS during HAART therapy. The model equations incorporate physiological interactions between non-infected helper T cells, HIV-1 infected helper T cells, HIV-1 virions in the blood plasma, HIV-1 specific cytotoxic T cells and drug molecules of the HAART protocol. Investigative computer simulations are performed to elucidate some therapeutic scenarios such as viral annihilation and efficacious HAART therapy. In particular, some mathematical criteria are derived for therapeutic outcomes such as viral persistence and viral annihilation.
Keywords :
blood; cellular biophysics; diseases; drugs; medical computing; patient treatment; physiological models; toxicology; HAART therapy; HIV-1 AIDS; HIV-1 infected helper T cells; HIV-1 specific cytotoxic T cells; HIV-1 virions; blood plasma; drug molecules; mathematical model; noninfected helper T cells; pathophysiological dynamics; viral annihilation; viral persistence; Cells (biology); Computational modeling; Computer simulation; Drugs; Mathematical model; Protocols; AIDS cure criteria; HAART therapy; HIV-1 dynamics; computer simulations; mathematical modeling;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-9351-7
DOI :
10.1109/BMEI.2011.6098678
