Title :
The scoring function based on amino acid network
Author :
Jiao, Xiong ; Yang, Lifeng
Author_Institution :
Inst. of Appl. Mech. & Biomed. Eng., Taiyuan Univ. of Technol., Taiyuan, China
Abstract :
With the contact energy between residues as the weight, we constructed a weighted amino acid network. Two parameters are introduced. Based on this network model, we proposed a new docking scoring function Sn. For 42 systems´ bound docking results, we do the scoring sort with this scoring function. Comparing the results got from this new scoring function with that from the RP scoring function, we find that the Sn scoring function has a better performance than the RP on some items.
Keywords :
bioinformatics; molecular biophysics; molecular configurations; physiological models; proteins; contact energy; docking scoring function; network model; weighted amino acid network; Amino acids; Bioinformatics; Complex networks; Correlation; Protein engineering; Proteins; Tin; amino acid network; network parameter; protein-protein docking; scorning function; unbound docking;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-9351-7
DOI :
10.1109/BMEI.2011.6098684
