DocumentCode :
2591670
Title :
Very high sensitivity CMOS circuit to track fast biological current signals
Author :
Ferrari, Giorgio ; Gozzini, Fabio ; Sampietro, Marco
Author_Institution :
Dipt. di Elettron. e Inf., Politec. di Milano, Milan
fYear :
2006
fDate :
Nov. 29 2006-Dec. 1 2006
Firstpage :
53
Lastpage :
56
Abstract :
The paper presents a novel transimpedance amplifier to sense very small and fast biological signals even in the presence of a dc leakage current as high as few tens of nanoamperes. The circuit, integrated on standard 0.35 mum CMOS technology, has a core based on the series of an integrator and a differentiator stage but features an additional time continuous feedback loop to discharge the standing current from the device under test, thus ensuring an unlimited measuring time opportunity with no need of reset pulses. This amplifier is ideal in a wide range of applications in miniaturized single chip systems such as implantable electronics, single molecules characterization or sensor interfaces, where very high sensitivity is requested together with minimum amount of biological matter and of analyte.
Keywords :
CMOS integrated circuits; MOSFET; MOSFET circuits; amplifiers; bioelectric phenomena; biological techniques; circuit feedback; differentiating circuits; electric sensing devices; integrating circuits; leakage currents; 0.35 mum CMOS technology; CMOS circuit; MOSFET; biological sensor; dc leakage current; fast biological current signal tracking; integrator-differentiator stage series; size 0.35 micron; time continuous feedback loop; transimpedance amplifier; CMOS technology; Circuit testing; Feedback circuits; Feedback loop; Integrated circuit technology; Leakage current; Measurement standards; Nanobioscience; Pulse amplifiers; Pulse measurements;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Circuits and Systems Conference, 2006. BioCAS 2006. IEEE
Conference_Location :
London
Print_ISBN :
978-1-4244-0436-0
Electronic_ISBN :
978-1-4244-0437-7
Type :
conf
DOI :
10.1109/BIOCAS.2006.4600306
Filename :
4600306
Link To Document :
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