Title :
Real-time monitoring on peptide synthesis by GMR biosensors
Author :
Lue, Jiann-Hwa ; Ding, Ting-Jou ; Yang, Tsung-Hsun ; Chang, Jenq-Yang ; Chen, Wen-Yih
Author_Institution :
Dept. of Opt. & Photonics, Nat. Central Univ., Chungli, Taiwan
Abstract :
In this work, a real-time monitoring system has been developed. The micro-optic device applying the guided-mode resonance (GMR) effect has been designed and fabricated. By combining a simple and low cost microfluidic channel, the GMR measurement for detecting peptide synthesis reaction has been explored. It is able to determine whether or not the chemical reaction reacts and how far the chemical reaction arrived. In addition, the kinetics analysis for the peptide synthesis has also been discussed. It is successfully demonstrated that the GMR device is capable of monitoring the process of peptide synthesis in real time.
Keywords :
biochemistry; biosensors; microfluidics; organic compounds; GMR biosensor; guided mode resonance effect; kinetics analysis; microfluidic channel; microoptic device; peptide synthesis; real time monitoring system; Amino acids; Biosensors; Chemicals; Kinetic theory; Optical waveguides; Peptides; Real time systems; guided-mode resonance; kinetics analysis; peptide synthesis; real-time monitoring system; waveguide;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-9351-7
DOI :
10.1109/BMEI.2011.6098754
