Title :
Cytochrome c release caused by Pulsed Electric Fields (PEFs) with different time durations
Author :
Wu, Hao ; Wu, Minghe ; Zou, Heng
Author_Institution :
Sch. of Phys. Electron., Univ. of Electron. Sci. & Technol. of China (UESTC), Chengdu, China
Abstract :
Multilayer Dielectric Sphere Model (MDSM) is used for analyzing responses of cells to Pulsed Electric Fields (PEFs), and cytochrome c release is significant effect of PEFs when mitochondrial substructures are taken into account. Numerical results of MDSM model explain and verify the reported experimental results on Intracellular Electro-manipulation (IEM). It is proposed that two-step process of cytochrome c release can be implemented by bioelectric impulse effect on mitochondria.
Keywords :
biological effects of fields; cellular biophysics; bioelectric impulse effect; cytochrome c release; intracellular electromanipulation; mitochondrial substructures; multilayer dielectric sphere model; pulsed electric fields; Biological system modeling; Biomembranes; Conductivity; Dielectrics; Electric fields; Nonhomogeneous media; Plasmas; Cytochrome c Release; Intracellular Electro-manipulation; Multilayer Dielectric Sphere Model; Pulsed Electric Field;
Conference_Titel :
Microwave and Millimeter Wave Circuits and System Technology (MMWCST), 2012 International Workshop on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4673-1893-8
DOI :
10.1109/MMWCST.2012.6238126
