Conditioning-based model for the regulatory activities of microRNAs in specific dietary contexts

Author

Zhao, Chen ; Ivanov, Ivan ; Shah, Manasvi ; Davidson, Laurie A. ; Chapkin, Robert S. ; Dougherty, Edward R.

Author_Institution

Dept. of Electr. & Comput. Eng., Texas A&M Univ., College Station, TX, USA

fYear

2010

fDate

10-12 Nov. 2010

Firstpage

1

Lastpage

4

Abstract

For the first time, we studied the applicability of a conditioning-based model to a heterogeneous data set composed of expression values for microRNA, total mRNA and polysomal mRNA resulting from experiments about two dietary contexts. The results suggest that some of the microRNAs are likely to be involved in the regulation of a large set of genes and not just their putative targets. Furthermore, the regulatory activities of intestinal microRNA appear to be dependent on the sub-cellular location of mRNA within the cell.

Keywords

cellular biophysics; genetics; molecular biophysics; conditioning based model; gene regulation; heterogeneous data set; microRNA expression values; microRNA regulatory activities; polysomal mRNA; specific dietary context; subcellular mRNA location; total mRNA; Animals; Cancer; Colon; Context; Genomics; Histograms; Master-slave;

fLanguage

English

Publisher

ieee

Conference_Titel

Genomic Signal Processing and Statistics (GENSIPS), 2010 IEEE International Workshop on

Conference_Location

Cold Spring Harbor, NY

ISSN

2150-3001

Print_ISBN

978-1-61284-791-7

Type

conf

DOI

10.1109/GENSIPS.2010.5719690

Filename

5719690