Evaporative pumping of liquid in nanochannel for electrical measurement of a single biomolecule in nanofluidic format

Author

Lennon, Erwan ; Yamamoto, Takatoki ; Lee, Sang Wook ; Fujii, Teruo

Author_Institution

Fujii Lab., Univ. of Tokyo, Tokyo

fYear

2007

fDate

2-5 Aug. 2007

Firstpage

562

Lastpage

565

Abstract

We present a solution to obtain planar micro-electrodes self-aligned around a nanochannel drilled using focused ion beam (FIB) machining . The inter-electrode spacing is exactly that of the width of the nanochannel (100 to 600 nm ). The system is sealed with a PDMS (polydimethylsiloxane) thin foil that includes microfluidic channels. We are aiming at manipulation and characterization of single biomolecules by taking advantages of electrical measurements at nanoscale. As a result of pumping in the nanochannel, it has been observed that high-speed motion of DNA molecules due to evaporation-coupled capillary action. Electrical detection and measurements are currently being conducted.

Keywords

biomedical electrodes; focused ion beam technology; microelectrodes; microfluidics; molecular biophysics; nanobiotechnology; DNA molecules; PDMS; biomolecule; electrical measurement; evaporation-coupled capillary; evaporative pumping; focused ion beam machining; interelectrode spacing; nanochannel; nanofluidics; planar microelectrodes; polydimethylsiloxane; Electric variables measurement; Molecular biophysics; Nanotechnology; DNA; nano-gap electrode; nanochannel; nanofluidic device; single-molecular detection;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on

Conference_Location

Hong Kong

Print_ISBN

978-1-4244-0607-4

Electronic_ISBN

978-1-4244-0608-1

Type

conf

DOI

10.1109/NANO.2007.4601254

Filename

4601254