Title :
Development of a flexible PCO2 microsensor for gastrointestinal pHi monitoring
Author :
Sacristan, Emilio ; Peura, Robert A. ; Shahnarian, Albert ; Fiddian-Green, Richard
Author_Institution :
Dept. of Biomed. Eng., Worcester Polytech. Inst., MA, USA
Abstract :
The intramucosal pH (pHi) is indirectly determined by measuring the PCO2 in the lumen of the gut, and the bicarbonate ion concentration in an arterial blood sample; the pHi is then calculated using the Henderson-Hasslebach equation. A microsensor is developed to measure the intramural PCO2. The microsensor is designed as part of a flexible catheter for insertion into the colon or stomach. The sensor satisfied all accuracy and performance criteria after being tested in vivo. The in vivo performance was validated in pigs, with induced intestinal ischemia by comparing the sensor pHi measurements to those determined using a balloon tanometer and a needle pH electrode directly placed in the mucosal tissue
Keywords :
biomedical equipment; pH measurement; Henderson-Hasslebach equation; arterial blood sample; balloon tanometer; bicarbonate ion concentration; colon; flexible PCO2 microsensor; flexible catheter; gastrointestinal pHi monitoring; gut lumen; induced intestinal ischemia; intramucosal pH; microsensor; needle pH electrode; pigs; stomach; Blood; Catheters; Colon; Equations; In vivo; Intestines; Ischemic pain; Microsensors; Stomach; Testing;
Conference_Titel :
Bioengineering Conference, 1991., Proceedings of the 1991 IEEE Seventeenth Annual Northeast
Conference_Location :
Hartford, CT
Print_ISBN :
0-7803-0030-0
DOI :
10.1109/NEBC.1991.154620
