Title :
The Nature of Proteins
Author :
Rajasekaran, E. ; Vinobha, C.S. ; Vijayasarathy, M. ; Senthil, R. ; Sankarganesh, P.
Author_Institution :
Dept. of Biotechnol., Periyar Maniammai Univ., Thanjavur, India
Abstract :
There is lot of work gone into proteins to understand the nature of proteins. Hydrophobic interaction is the dominant force that drives the proteins to carry out the biochemical reactions in all living being. Carbon is the only element that contributes towards this hydrophobic interaction. In this study the carbon distribution along the protein sequence has been computed by representing the protein sequence as a series of atoms instead of amino acids. Given any length, there is a maximum frequency occurs at 31.44% of carbon. That is any globular proteins prefer to have 31.44% of carbon. This is not only in global but also in local. This newly identified carbon distribution profile is hoped to help in identification and development of active sites, study of protein stability, evolutionary understating of proteins, gene identification and to solve the long-standing problem of protein-protein and protein-DNA specific and non-specific interactions. This can also distinguish poisonous, viral and diseased proteins from the normal one.
Keywords :
DNA; biochemistry; carbon; evolution (biological); genetics; hydrophobicity; molecular biophysics; proteins; C; biochemical reaction; carbon distribution; diseased protein; gene identification; globular proteins; hydrophobic interaction; poisonous protein; protein evolution; protein nature; protein sequence; protein stability; protein-DNA interaction; protein-protein interaction; Amino acids; Bioinformatics; Biomedical engineering; Biotechnology; Computer science; Frequency conversion; Protein engineering; Protein sequence; Sequences; Springs; carbon analysis; carbon distribution; carbon profile; hydrophobicity;
Conference_Titel :
Computer Science and Information Technology - Spring Conference, 2009. IACSITSC '09. International Association of
Conference_Location :
Singapore
Print_ISBN :
978-0-7695-3653-8
DOI :
10.1109/IACSIT-SC.2009.46