Čerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip

Author

Cho, LS ; Douraghy, A. ; Olma, S. ; Liu, K. ; Chen, Y.C. ; Shen, C.K. ; Silverman, R.W. ; van Dam, R.M. ; Chatziioannou, Arion F.

Author_Institution

UCLA School of Medicine, Department of Pharmacology, Crump Institute at 700 Westwood Plaza, Los Angeles, CA, 90095-1770, USA

fYear

2008

fDate

19-25 Oct. 2008

Firstpage

4510

Lastpage

4515

Abstract

This work proposes a novel method for quantitative imaging of radioactivity on microfluidic chips by using visible light emission from Čerenkov radiation. Čerenkov radiation is generated when charged particles travel through an optically transparent material with a velocity greater than that of light in that material. It has been observed at UCLA that microfluidic chips used for ¹⁸F-related radio-synthesis studies have shown unidentified visible light emissions. In this study, the origin of the light was investigated and its feasibility as a quantitative imaging source was tested.

Keywords

Beta rays; Microfluidics; Optical imaging; Optical materials; Particle measurements; Radiation imaging; Radioactive materials; Semiconductor device measurement; Stimulated emission; Testing; Čerenkov radiation; Beta particles; charged coupled device (CCD); microfluidic chips;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2008. NSS '08. IEEE

Conference_Location

Dresden, Germany

ISSN

1095-7863

Print_ISBN

978-1-4244-2714-7

Electronic_ISBN

1095-7863

Type

conf

DOI

10.1109/NSSMIC.2008.4774293

Filename

4774293