Title :
A CMOS Integrated DNA-chip for hybridization detection with digital output
Author :
Barbaro, Massimo ; Caboni, Alessandra ; Loi, Daniela
Author_Institution :
Univ. of Cagliari, Cagliari
Abstract :
A CMOS integrated circuit hosting an array of 80 sensors for DNA hybridization detection was designed. Each biosensor is made up of a FET device whose current is modulated by DNA electric charge. The chip incorporates integrated temperature detection for precise assay control and features programmable signal conditioning, amplification and A/D conversion. Successful pre-and post-layout simulations are provided.
Keywords :
CMOS integrated circuits; DNA; analogue-digital conversion; biosensors; field effect transistors; A/D conversion; CMOS integrated DNA-chip; CMOS integrated circuit; DNA electric charge; FET device; biosensor; digital output; hybridization detection; integrated temperature detection; precise assay control; Biosensors; CMOS process; DNA; FETs; MOSFETs; Sensor arrays; Sequences; Substrates; Testing; Threshold voltage;
Conference_Titel :
Advances in Sensors and Interface, 2007. IWASI 2007. 2nd International Workshop on
Conference_Location :
Bari
Print_ISBN :
978-1-4244-1245-7
Electronic_ISBN :
978-1-4244-1245-7
DOI :
10.1109/IWASI.2007.4420012
