Title :
Monitoring angiogenesis in human melanoma xenografts using contrast-enhanced ultrasound
Author :
Ro, Raymond J. ; Forsberg, Flemming ; Liu, Ji-Bin ; James, Kathryn M. ; Potoczek, Magdalena ; Lewin, Peter A. ; Nazarian, Levon N.
Author_Institution :
Sch. of Biomedical Eng., Drexel Univ., Philadelphia, PA, USA
Abstract :
In mice implanted with human melanoma xenografts, this study set out to determine if a correlation exists between noninvasive contrast-enhanced ultrasound measures of tumor neovascularity with invasive histologic specimens stained with angiogenesis markers CD31, COX-2, and VEGF. Results indicate that ultrasound, in conjunction with the use of contrast media, may provide a noninvasive marker for angiogenesis.
Keywords :
biomedical ultrasonics; patient monitoring; tumours; angiogenesis markers; angiogenesis monitoring; human melanoma xenografts; invasive histologic specimens; mice; noninvasive contrast-enhanced ultrasound; tumor neovascularity; Animals; Frequency; Humans; Malignant tumors; Mice; Monitoring; Neoplasms; Regulators; Ultrasonic imaging; Ultrasonic variables measurement;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on
Print_ISBN :
0-7803-8388-5
DOI :
10.1109/ISBI.2004.1398589
