Fabrication of PDMS Scaffold with Controlled Configurations

Author

Masuda, Taisuke ; Anada, Takahisa ; Takahashi, Ichiro ; Arai, Fumihito ; Fukuda, Toshio ; Suzuki, Osamu

Author_Institution

Tohoku Univ., Sendai

fYear

2007

fDate

11-14 Nov. 2007

Firstpage

362

Lastpage

367

Abstract

In this study, we tried to create a polydimethyl -siloxane (PDMS) scaffold with controlled pore configurations to investigate the proliferation and differentiation of the cells seeded 3-dimensionally. The three-dimensional scaffold was designed to investigate the effect of mechanical stress to the cells by utilizing the intrinsic elasticity of the PDMS. We used a combination of casting mold and lamination process to fabricate PDMS scaffold with controlled pore configuration. The lamination of each PDMS layer resulted in a construct with three-directionally interconnected micropores (600times600 mum in section) as a PDMS body.

Keywords

bioMEMS; biomechanics; casting; cellular biophysics; laminations; molecular biophysics; moulding; polymers; tissue engineering; PDMS scaffold; casting mold; controlled configurations; controlled pore configurations; elasticity; lamination process; mechanical stress; polydimethyl-siloxane scaffold; seeded 3-dimensionally cell; three-directionally interconnected micropores; Biodegradable materials; Biological materials; Capacitive sensors; Cells (biology); Fabrication; In vitro; Lamination; Morphology; Stress; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro-NanoMechatronics and Human Science, 2007. MHS '07. International Symposium on

Conference_Location

Nagoya

Print_ISBN

978-1-4244-1858-9

Electronic_ISBN

978-1-4244-1858-9

Type

conf

DOI

10.1109/MHS.2007.4420881

Filename

4420881