Adaptive finite element methods for fluorescence enhanced frequency domain optical tomography: forward imaging problem

Author

Joshi, Amit ; Bangerth, Wolfgang ; Thompson, Alan B. ; Sevick-Muraca, Eva M.

Author_Institution

Photon Migration Lab., Texas A&M Univ., College Station, TX, USA

fYear

2004

fDate

15-18 April 2004

Firstpage

1103

Abstract

In this contribution we introduce adaptive finite element methods for forward modeling in fluorescence optical tomography. Adaptive local mesh refinement increases the accuracy of the solutions of coupled photon diffusion equations in a computationally optimal manner and when implemented in the inverse problem, can impact the resolution of fluorescence enhanced tomography. An adaptive Galerkin finite element scheme is implemented and the simulation results are compared with experimental data obtained from a tissue phantom by an area illumination and area detection scheme.

Keywords

Galerkin method; biological tissues; biomedical optical imaging; fluorescence; image enhancement; image resolution; inverse problems; medical image processing; mesh generation; optical tomography; phantoms; adaptive Galerkin finite element methods; adaptive local mesh refinement; area detection scheme; area illumination scheme; coupled photon diffusion equations; fluorescence enhanced frequency domain optical tomography; forward imaging problem; image resolution; inverse problem; tissue phantom; Adaptive optics; Computational modeling; Equations; Finite element methods; Fluorescence; Frequency domain analysis; Inverse problems; Optical computing; Optical imaging; Single photon emission computed tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on

Print_ISBN

0-7803-8388-5

Type

conf

DOI

10.1109/ISBI.2004.1398735

Filename

1398735