Continuous plasma separation from whole blood using microchannel geometry

Author

Park, J. ; Cho, K. ; Chung, C. ; Han, D.-C. ; Chang, J.K.

Author_Institution

Sch. of Mech. & Aerosp. Eng., Seoul Nat. Univ., South Korea

fYear

2005

fDate

12-15 May 2005

Firstpage

8

Lastpage

9

Abstract

Plasma separation from whole blood using microfluidics was investigated. We suggested modified channel geometry called "corner-edge" to enhance plasma skimming effect at branching channel. To evaluate separation efficiency, microfluidic chip was fabricated with silicone elastomer and glass. The efficiency of separation was above 99% comparing with whole blood hematocrit. This microfluidic unit could be integrated with microchannel network for lab-on-a-chip applications such as immunoassay.

Keywords

biological techniques; blood; cellular biophysics; elastomers; glass; microchannel flow; silicones; blood; branching channel; continuous plasma separation; corner-edge channel; glass; immunoassay; lab-on-a-chip application; microchannel geometry; microchannel network; microfluidic chip fabrication; plasma skimming effect; separation efficiency; silicone elastomer; Blood; Geometry; Glass; Immune system; Microchannel; Microfluidics; Plasma applications; Plasma measurements; Plasma properties; Reservoirs; immunoassay; microfluidics; plasma separation;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on

Print_ISBN

0-7803-8711-2

Type

conf

DOI

10.1109/MMB.2005.1548368

Filename

1548368