Title :
Traveling wave bio-agent concentrator
Author :
Lean, Meng H. ; Völkel, Armin R. ; Hsieh, H.B. ; Lu, Jeng-P ; Daniel, Jürgen H. ; Preas, Bryan T. ; Limb, Scott J.
Author_Institution :
Palo Alto Res. Center, CA, USA
Abstract :
This paper describes a hybrid bio-agent concentrator device based on the combined performance of a modified field flow fractionation system for particulate deposition and a traveling wave transport mechanism to deliver and concentrate particulates into a sample well. The device has been successfully tested on B. thurengiensis and polystyrene beads in the threat range of 1-10 μm. This MEMS device may increase the concentration of post-ultrafiltration retentates or post-aerosol collected hydrosols by another 100X. As a front-end to detection, it will enhance the effective sensitivity of the detector. The device may also have bio medical implications in bio separation and cell enrichment.
Keywords :
biological techniques; electrostatic devices; fractionation; micromechanical devices; microorganisms; B. thurengiensis; MEMS device; biomedical implication; bioseparation; cell enrichment; detector sensitivity; field flow fractionation system; hydrosols; particulate deposition; polystyrene beads; post-aerosol collection; post-ultrafiltration retentation; traveling wave bio-agent concentrator; traveling wave transport mechanism; Aerosols; Detectors; Electrodes; Electrostatics; Fabrication; Field-flow fractionation; Microelectromechanical devices; Phased arrays; Testing; Voltage;
Conference_Titel :
Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on
Print_ISBN :
0-7803-8711-2
DOI :
10.1109/MMB.2005.1548389
