Title :
Multirate MPC design for a nonlinear drug infusion system
Author :
Gopinath, Ravi S. ; Bequette, B. Wayne ; Roy, Rob J. ; Kaufman, Howard
Author_Institution :
Dept. of Chem. Eng., Rensselaer Polytech. Inst., Troy, NY, USA
fDate :
29 June-1 July 1994
Abstract :
Multivariable controller design for the regulation of blood pressure and flowrate in congestive heart failure patients is typically limited by the sample time for blood flowrate. We present a multirate model predictive control (MPC) design for the multidrug infusion problem, based on a comprehensive nonlinear model of the system. The MPC design is based on NL-QDMC, with a selective linearization method introduced to reduce computation time. External constraints on dopamine infusion specify a ´forbidden zone´ in addition to upper and lower bounds. The multirate MPC design includes a novel rule-based override that is used to avoid any infusion in this region. Simulation results are used to illustrate the performance of the controller.
Keywords :
biomedical equipment; blood; linearisation techniques; multivariable control systems; nonlinear control systems; patient treatment; predictive control; blood flowrate regulation; blood pressure regulation; comprehensive nonlinear model; computation time; congestive heart failure patients; dopamine infusion; forbidden zone; lower bounds; multidrug infusion problem; multirate model predictive control design; multivariable controller design; nonlinear drug infusion system; rule-based override; selective linearization method; upper bounds; Arteries; Blood pressure; Circulatory system; Design engineering; Drug delivery; Heart; Immune system; Nonlinear equations; Predictive models; Pressure control;
Conference_Titel :
American Control Conference, 1994
Print_ISBN :
0-7803-1783-1
DOI :
10.1109/ACC.1994.751703
