A fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS process

Author

Huang, Che-Wei ; Huang, Yu-Jie ; Yen, Pei-Wen ; Hsueh, Hsiao-Ting ; Lin, Chia-Yi ; Chen, Min-Cheng ; Ho, ChiaHua ; Yang, Fu-Liang ; Tsai, Hann-Huei ; Liao, Hsin-Hao ; Juang, Ying-Zong ; Wang, Chorng-Kuang ; Lin, Chih-Ting ; Lu, Shey-Shi

Author_Institution

Nat. Taiwan Univ., Taipei, Taiwan

fYear

2012

fDate

13-15 June 2012

Firstpage

124

Lastpage

125

Abstract

Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated.

Keywords

CMOS integrated circuits; DNA; biomedical electronics; biosensors; choppers (circuits); elemental semiconductors; microorganisms; monolithic integrated circuits; nanosensors; nanowires; radiofrequency integrated circuits; silicon; system-on-chip; temperature sensors; Si; base-pair mismatched DNA; chopper DDA-based analog front-end; fully integrated hepatitis B virus DNA detection SoC; high CMRR; monolithic polysilicon nanowire CMOS process; polysilicon nanowire based biosensor; standard CMOS SoC; temperature drift compensation; temperature sensor; wireless acquisition circuits; Biosensors; DNA; System-on-a-chip; Temperature sensors; Wireless communication; Wireless sensor networks;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits (VLSIC), 2012 Symposium on

Conference_Location

Honolulu, HI

Print_ISBN

978-1-4673-0848-9

Electronic_ISBN

978-1-4673-0845-8

Type

conf

DOI

10.1109/VLSIC.2012.6243821

Filename

6243821