A fully-electronic charge-based DNA sequencing CMOS biochip

Author

Manickam, Arun ; Singh, Rituraj ; Wood, Nicholas ; Li, Bingling ; Ellington, Andrew ; Hassibi, Arjang

Author_Institution

Electr. & Comput. Eng. Dept., Univ. of Texas at Austin, Austin, TX, USA

fYear

2012

fDate

13-15 June 2012

Firstpage

126

Lastpage

127

Abstract

A 90×90 fully-electronic biosensor array for charge-based DNA sequence-by-synthesis is implemented in a 0.18μm standard CMOS process. Each 16 μm × 16 μm pixel consists of an integrated charge-sensing electrode connected to an embedded circuitry capable of detecting DNA polymerization and simultaneously measuring the electrode-electrolyte interface capacitance. The detection dynamic range of this sensor is +90dB while consuming 4 mW from a 3.3V supply when operating at 8.1s/frame.

Keywords

CMOS integrated circuits; DNA; biosensors; lab-on-a-chip; sensor arrays; DNA polymerization detection; charge-based DNA sequence-by-synthesis; electrode-electrolyte interface capacitance; embedded circuitry; fully-electronic biosensor array; fully-electronic charge-based DNA sequencing CMOS biochip; integrated charge-sensing electrode; power 4 mW; size 0.18 mum; standard CMOS process; voltage 3.3 V; Arrays; CMOS integrated circuits; Current measurement; DNA; Electrodes; Polymers; Scattering; DNA sequencing; ISFET; biosensor;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits (VLSIC), 2012 Symposium on

Conference_Location

Honolulu, HI

Print_ISBN

978-1-4673-0848-9

Electronic_ISBN

978-1-4673-0845-8

Type

conf

DOI

10.1109/VLSIC.2012.6243822

Filename

6243822