Title :
A fully-electronic charge-based DNA sequencing CMOS biochip
Author :
Manickam, Arun ; Singh, Rituraj ; Wood, Nicholas ; Li, Bingling ; Ellington, Andrew ; Hassibi, Arjang
Author_Institution :
Electr. & Comput. Eng. Dept., Univ. of Texas at Austin, Austin, TX, USA
Abstract :
A 90×90 fully-electronic biosensor array for charge-based DNA sequence-by-synthesis is implemented in a 0.18μm standard CMOS process. Each 16 μm × 16 μm pixel consists of an integrated charge-sensing electrode connected to an embedded circuitry capable of detecting DNA polymerization and simultaneously measuring the electrode-electrolyte interface capacitance. The detection dynamic range of this sensor is +90dB while consuming 4 mW from a 3.3V supply when operating at 8.1s/frame.
Keywords :
CMOS integrated circuits; DNA; biosensors; lab-on-a-chip; sensor arrays; DNA polymerization detection; charge-based DNA sequence-by-synthesis; electrode-electrolyte interface capacitance; embedded circuitry; fully-electronic biosensor array; fully-electronic charge-based DNA sequencing CMOS biochip; integrated charge-sensing electrode; power 4 mW; size 0.18 mum; standard CMOS process; voltage 3.3 V; Arrays; CMOS integrated circuits; Current measurement; DNA; Electrodes; Polymers; Scattering; DNA sequencing; ISFET; biosensor;
Conference_Titel :
VLSI Circuits (VLSIC), 2012 Symposium on
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-4673-0848-9
Electronic_ISBN :
978-1-4673-0845-8
DOI :
10.1109/VLSIC.2012.6243822
