Title :
Micro valve system for individual cell transportation in microfluidic chip
Author :
Hasegawa, Akiyuki ; Uvet, Huseyin ; Ohara, Kenichi ; Takubo, Tomohito ; Mae, Yasushi ; Arai, Tatsuo
Author_Institution :
Dept. of Syst. Innovation, Osaka Univ., Osaka, Japan
Abstract :
Recently, micro valves to control some kinds of fluids in channels in a microchip have been developed. Now we pay attention to in-chip somatic cell cloning with microfluidic technology. There are some steps, cell supply, cutting, sorting, coupling, fusion and so on, for this work. And we focused on a cell supply system spending cells one by one in microfluidic chip, and attempt to transport an individual cell to objective course by the control of pressure valves. Here, we made three kinds valves, a) open channel 2-layer valve, b) open channel 3-layer valve, and c) close channel 2-layer valve. We compare these valves about interception condition of micro channel flow and time to take for open/close. And then we evaluated them with suitable for the smooth cell transportation by these comparisons.
Keywords :
bioMEMS; cellular biophysics; microfluidics; close channel 2-layer valve; individual cell transportation; microfluidic chip; microvalve system; open channel 2-layer valve; open channel 3-layer valve; Biological materials; Cells (biology); Cloning; Control systems; Microfluidics; Microvalves; Space technology; Technological innovation; Transportation; Valves;
Conference_Titel :
Micro-NanoMechatronics and Human Science, 2009. MHS 2009. International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4244-5094-7
Electronic_ISBN :
978-1-4244-5095-4
DOI :
10.1109/MHS.2009.5352073