Title :
Modelling of repeated fed-batch fermentation process for L-Lysine production
Author :
Georgiev, Tz ; Todorov, K. ; Dimov, I. ; Ivanova, V. ; Kristeva, J. ; Ratkov, A.
Author_Institution :
Fac. of Automatics, Tech. Univ., Sofia
Abstract :
This article deals with modelling of dynamic unstructured model of variable volume fed-batch fermentation process with intensive droppings for L-lysine production. The presented approach of the investigation includes the following main procedures: description of the process by generalized stoichiometric equations; preliminary data processing and calculation of specific rates for main kinetic variables; identification of the specific rates (growth rate (mu), substrate utilization rate (nu), production rate (rho) as a second-order non-linear dynamic models; establishment and optimization of dynamic model of the process; simulation researches. MATLAB is used as a research environment
Keywords :
batch processing (industrial); biotechnology; fermentation; mathematics computing; nonlinear dynamical systems; optimisation; L-lysine production; MATLAB; generalized stoichiometric equation; intensive dropping; modelling; nonlinear dynamic model; optimization; preliminary data processing; repeated fed-batch fermentation process; Amino acids; Automation; Data processing; Feeds; Kinetic theory; MATLAB; Mathematical model; Nonlinear equations; Production; Sugar;
Conference_Titel :
Information Technology Interfaces, 2006. 28th International Conference on
Conference_Location :
Cavtat/Dubrovnik
Print_ISBN :
953-7138-05-4
DOI :
10.1109/ITI.2006.1708536
