Title :
Apertureless near-field fluorescence microscope for biological imaging
Author :
Gerton, J.M. ; Lessard, G.A. ; Wade, L.A. ; Quake, S.R.
Author_Institution :
Div. of Appl. Phys., California Inst. of Technol., Pasadena, CA, USA
Abstract :
We measured the optical response of fluorescent beads to sharp metallic and semiconducting probes, revealing several underlying near-field interactions. Our results suggest that /spl sim/10 nanometer optical resolution with spectroscopic chemical sensitivity is possible, and bear strongly on molecular-scale biological imaging.
Keywords :
biological techniques; biomedical optical imaging; fluorescence; molecular biophysics; optical microscopy; apertureless fluorescence microscope; biological imaging; fluorescent beads; metallic probes; near-field fluorescence microscope; near-field interactions; optical resolution; semiconducting probes; spectroscopic chemical sensitivity; Biomedical optical imaging; Fluorescence; Image resolution; Microscopy; Nanobioscience; Optical imaging; Optical sensors; Probes; Semiconductivity; Spectroscopy;
Conference_Titel :
Quantum Electronics and Laser Science, 2003. QELS. Postconference Digest
Conference_Location :
Baltimore, MD, USA
Print_ISBN :
1-55752-749-0
DOI :
10.1109/QELS.2003.238509
