Title :
Mechanochemical theory for the ATP-fuelled biomolecular motors
Author :
Liu, Ming S. ; Todd, B.D. ; Sadus, Richard J.
Author_Institution :
Centre for Molecular Simulation, Swinburne Univ. of Technol., Hawthorn, Vic.
Abstract :
Biomolecular motors are normally single or complex biomolecules exerting mechanical forces across molecular and cellular scales. The ATP-fuelled biomolecular motors can transduce the chemical energy from ATP hydrolysis into forces and motions in cells. In biomolecular motors, transport reactions are both stoichiometric and enzymatic. We set up a mechanochemical theory for biomolecular motors to understand its enzymatic kinetics and continuous dynamics. This theory is validated by modeling the operating mechanism and dynamics of several ATP-fuelled molecular motors driving various loads
Keywords :
biomechanics; molecular biophysics; ATP hydrolysis; ATP-fuelled biomolecular motors; continuous dynamics; enzymatic kinetics; mechanochemical theory; stoichiometric; Australia Council; Biochemistry; Chemical technology; Kinetic theory; Mechanical factors; Micromotors; Molecular biophysics; Power generation; Proteins; Thermodynamics;
Conference_Titel :
Robotics and Biomimetics (ROBIO). 2005 IEEE International Conference on
Conference_Location :
Shatin
Print_ISBN :
0-7803-9315-5
DOI :
10.1109/ROBIO.2005.246290
