Title :
Molecular dynamics simulation of the bio-adhesion in molecular motors
Author :
Yang, Zhenyu ; Ren, Quan ; Zhao, Ya-Pu
Author_Institution :
Inst. of Mech., Chinese Acad. of Sci., Beijing
Abstract :
Molecular dynamics (MD) simulation is employed to study the bio-adhesion in F1 ATP molecular motor. Histidine-peptide is widely used as linkage in micro systems because of its strong binding strength to metals. This paper focuses on the adhesion between a synthetic peptide containing 6timeshis-tag (Gly-Gly-Lys-Gly-Gly-LysGly-GIy-His-His-His-His-His-His) and metal substrate, which is used to define the position of the F1 ATP molecular motor on the metal substrate. It is shown that the binding strength between histidine and nickel substrate is the strongest, while that of copper is smaller and that of gold substrate is the smallest. From the result of simulation, we find that the stability of adhesion between histidine and the metal substate result of the ringed structure in histidine
Keywords :
molecular biophysics; nanotechnology; bioadhesion; histidine-peptide; metal substrate; molecular dynamics simulation; molecular motors; nickel substrate; synthetic peptide; Adhesives; Amino acids; Biological system modeling; Copper; Gold; Nanobioscience; Nanoelectromechanical systems; Nickel; Peptides; Topology;
Conference_Titel :
Robotics and Biomimetics (ROBIO). 2005 IEEE International Conference on
Conference_Location :
Shatin
Print_ISBN :
0-7803-9315-5
DOI :
10.1109/ROBIO.2005.246291
