In Silico Assessment of Nanosecond Pulse Exposures of Cells, Tissues and Organs

Author

Gowrishankar, Thiruvallur ; Esser, Axel ; Smith, Kyle ; Weaver, James

Author_Institution

Div. of Health Sci. & Technol., Massachusetts Inst. of Technol., Cambridge, MA

fYear

2006

fDate

14-18 May 2006

Firstpage

506

Lastpage

506

Abstract

We have developed an in silico framework that integrates macro- and microdosimetry models, and incorporates biophysical mechanism models to estimate biochemical change resulting from exposure to nanosecond electrical pulses. This approach provides estimates of conductance changes and biochemical release/uptake within cells, local tissue regions and organs

Keywords

biochemistry; bioelectric phenomena; biological effects of fields; biological organs; biological tissues; biomembrane transport; cellular effects of radiation; dosimetry; biochemical analysis; biophysical mechanism models; cell exposures; electric conductance estimation; in silico assessment; macrodosimetry models; membrane transport; microdosimetry; nanosecond electrical pulse exposures; organs exposure; tissue effects; Biological system modeling; Biomembranes; Cells (biology); Finite difference methods; Impedance measurement; Lattices; Nanobioscience; Plasmas; Pulse generation; Time domain analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Power Modulator Symposium, 2006. Conference Record of the 2006 Twenty-Seventh International

Conference_Location

Arlington, VA

Print_ISBN

1-4244-0018-X

Electronic_ISBN

1-4244-0019-8

Type

conf

DOI

10.1109/MODSYM.2006.365295

Filename

4216247