Title :
Highly packed liposome assemblies toward synthetic tissue
Author :
Hamano, H. ; Tonooka, Taishi ; Osaki, T. ; Takeuchi, Shoji
Author_Institution :
Inst. of Ind. Sci., Univ. of Tokyo, Tokyo, Japan
Abstract :
This paper presented an approach for preparation of a highly-packed liposome assembly that implemented lipid bilayer-lipid bilayer contact at the interfaces to mimic a cell-cell connection on living tissues. Cell-sized liposomes were closely packed using our previous technique that allowed monodisperse liposomes arrayed on a substrate. We explored the lipid patterning conditions that would provide a packed structure of the liposomes. By further works, we believe that the assembled structure would be useful for a tissue model.
Keywords :
biological tissues; cellular biophysics; lipid bilayers; self-assembly; tissue engineering; cell-cell connection; cell-sized liposomes; highly-packed liposome assembly; lipid bilayer-lipid bilayer contact; lipid patterning conditions; living tissues; monodisperse liposomes; synthetic tissue; tissue model; Arrays; Assembly; Electrostatic discharges; Fluorescence; Lipidomics; Proteins; Substrates;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on
Conference_Location :
San Francisco, CA
DOI :
10.1109/MEMSYS.2014.6765562