Title :
Antitumor Effects of Typhonium giganteum Engl, Tuber Extracts
Author :
Song, Yanling ; Li, Baina ; Meng, Yanqiu
Author_Institution :
Dept. of Pharm. Eng., Shenyang Univ. of Chem. Technol., Shenyang, China
Abstract :
Aim: To study the antitumor activities of 70% ethanol extracts of Typhonium giganteum Engl. tuber in human Liver Cancer Bel-7402 and Lung Cancer A549 Cell Lines in vitro. Method: Bel-7402 and A549 cells proliferative activities were measured by MTT method in vitro. Cells apoptosis were analyzed by morphology analysis. Results: Bel-7402 and A549 cells were treated with of Typhonium giganteum Engl. tuber extracts (TGE) at concentrations from 1.0, 10.0 to 100.0 mg·L-1 for 24 to 72 h, cellular proliferation were inhibited with the increase of concentration and time. Compared with the control group, the significant apoptotic morphology changes were observed. Conclusion: 70% ethanol extracts of Typhonium giganteum Engl. tuber can decrease the proliferation rate and induce apoptosis of Bel-7402 and A549 cells. Taken together, these results suggested that Typhonium giganteum Engl. was a promising herbal drug in the therapy of human Liver Cancer and Lung Cancer.
Keywords :
botany; cancer; drugs; liver; lung; organic compounds; tumours; A549 cell lines; Bel-7402; Typhonium giganteum Engl; antitumor effects; cell apoptosis; cell proliferative activities; ethanol extracts; herbal drug; human liver cancer; in vitro MTT method; lung cancer; morphology analysis; tuber extracts; Cancer; Chemical technology; Drugs; Educational institutions; Ethanol; Humans; USA Councils; A549 cells; Bel-7402 cells; Typhonium giganteum Engl; antitumor activties;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.76