DocumentCode :
267838
Title :
Towards on-chip chemical reaction monitoring by EWOD impedance measurement
Author :
Xiaoxiao Ma ; Supin Chen ; Kim, Chang-Jin Cj ; van Dam, R. Michael
Author_Institution :
Dept. of Mol. & Med. Pharmacology, Univ. of California, Los Angeles, Los Angeles, CA, USA
fYear :
2014
fDate :
26-30 Jan. 2014
Firstpage :
338
Lastpage :
341
Abstract :
This paper demonstrates the use of impedance sensing in an electrowetting-on-dielectric (EWOD) chip to monitor the progress of a chemical reaction. Sensing is achieved by measuring the current through a sample droplet with the aid of a lock-in amplifier. Monitoring of the reaction of HCl with NaOH (i.e., during a titration) was demonstrated. A sharp minimum in the impedance signal was observed at the titration equivalence point, enabling the endpoint to be determined electronically. Future work is aimed at extending reaction monitoring to additional acid-base systems and other classes of reactions.
Keywords :
amplifiers; electric current measurement; electric impedance measurement; microprocessor chips; wetting; EWOD chip; acid-base systems; chemical reaction monitoring; current measurement; electrowetting-on-dielectric chip; equivalence point; impedance measurement; impedance sensing; impedance signal; lock-in amplifier; sample droplet; titration; Chemicals; Conductivity; Electrodes; Impedance; Impedance measurement; Monitoring; Sensors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on
Conference_Location :
San Francisco, CA
Type :
conf
DOI :
10.1109/MEMSYS.2014.6765645
Filename :
6765645
Link To Document :
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