Enantioseparation of Propranolol Enantiomers Using Hollow Fiber Membrane Contactor

This paper deals with the enantioseparation of racemic propranolol containing S, S-di-n-dodecylltartrate as a chiral carrier using hollow fiber membrane contactor (HFMC). A mathematical mass transfer model of enantioseparation process for chiral compounds was deduced, factors such as the observed partition coefficient between the feed phase and the hollow fibers, the stripping phase and the hollow fiber module, transportation resistance of boundary layers in the stripping phase and the feed phase, the diffusion resistance in the membrane phase are considered in this mathematical mass transfer model.