Expression of ADAM8 in Liver Cancer

Author

Li, San-Qiang ; Meng, Hong-Ye ; Xi, Shou-Min ; Ma, Ling-Jun ; Yang, Wu-Biao

Author_Institution

Dept. of Biochem. & Mol. Biol., Henan Univ. of Sci. & Technol., Luoyang, China

fYear

2012

fDate

28-30 May 2012

Firstpage

268

Lastpage

271

Abstract

ADAM8 (disintegrin and metalloprotease 8) belongs to a family of transmembrane proteins implicated in cell-cell interactions, proteolysis of membrane proteins, and various aspects of carcinogenesis. In this study, we want to evaluate whether ADAM8 is highly expressed in liver cancer. So western blot, RT-PCR and Immunohistochemistry were used to evaluate the expression of ADAM8 in liver cancer and normal liver. The results of western blot and RT-PCR show that ADAM8 is highly expressed in liver cancer. The result s of immunohistochemistry shows that ADAM8 is mainly expressed in the cytoplasm of liver cancer cells. Our results first prove that ADAM8 is expressed in the liver cancer, which may play important roles in the genesis and development of liver cancer.

Keywords

biochemistry; cancer; cellular biophysics; liver; molecular biophysics; patient diagnosis; proteins; ADAM8 expression; RT-PCR; Western blot test; carcinogenesis; cell-cell interaction; cytoplasm; disintegrin; immunohistochemistry; liver cancer cells; metalloprotease 8; proteolysis; transmembrane proteins; Biomembranes; Cancer; Educational institutions; Immune system; Liver; Proteins; Software; ADAM8; liver cancer;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on

Conference_Location

Macau, Macao

Print_ISBN

978-1-4577-1987-5

Type

conf

DOI

10.1109/iCBEB.2012.210

Filename

6245107