Title :
Synthesis of 5-Fluorouracil Acetic Acid Prodrugs of ß-Cyclodextrin at the Secondary Hydroxyl Side as Potential Colon-Specific Delivery Systems
Author :
Cheng, Jingui ; Wang, Zhizhong
Author_Institution :
Dept. of Chem. Eng., Shihezi Univ., Shihezi, China
Abstract :
The anticancer drug 5-fluorouracil-1-acetic acid was covalently attached to ß-cyclodextrin at the secondary hydroxyl side by using N, N-carbonyldiimidazole as a coupling reagent. The preliminary release behaviors of 5-fluorouracil-1-acetic acid in the gastrointestinal tract fluids of rats were studied at 37 °C, 5-Fluorouracil-1-acetic acid was almost released 52.6% from the conjugates after 24 h in the colonic fluids of rats, probably via the biodegradation by glycosidases and hydrolases.
Keywords :
biochemistry; biological organs; cancer; drugs; molecular biophysics; ß-cyclodextrin; 5-fluorouracil acetic acid prodrugs; 5-fluorouracil-1-acetic acid; N,N-carbonyldiimidazole; anticancer drug; biodegradation; colon-specific delivery system; gastrointestinal tract fluids; glycosidases; hydrolases; secondary hydroxyl side; temperature 37 C; Colon; Drugs; Fluids; Gastrointestinal tract; Rats; 5-fluorouracil-1-acetic acid; conjugate; cyclodextrin; hydrolysis;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.391
