Title :
The Synthesis of Evodiamine
Author :
Wang, Cheng-xue ; Xiong, Yu
Author_Institution :
Sch. of Chem. Eng., Changchun Univ. of Technol., Changchun, China
Abstract :
The e-carboline compound and evodiamine were synthesized with improved Bischler-Napieralski-type and Diels-Alder-type reactions by taking tryptamine and N-methyl anthranilic acid as starting materials, enjoying the characteristics of few steps, simple ness, mild reaction conditions, high productivity and less pollution etc. Conduct elementary analyses on the resulting compounds and characterize them with analyzing means such as IR, ESI-MS, 1H NMR and 13C NMR. In addition, regular MTT cytotoxicity tests were also performed, and three different time periods were formulated to determine its IC50.
Keywords :
chemical reactions; drugs; infrared spectra; mass spectra; materials testing; nuclear magnetic resonance; organic compounds; 13C NMR method; 1H NMR method; Bischler-Napieralski-type reaction; Diels-Alder-type reaction; ESI-MS method; IR method; MTT cytotoxicity test; N-methyl anthranilic acid; beta-carboline compound; elementary analysis; evodiamine synthesis; infrared spectroscopy; mass spectroscopy; nuclear magnetic resonance; tryptamine; Chemicals; Compounds; Detectors; Materials; Nuclear magnetic resonance; Productivity; 3; 4-dihydro-¦Â-carboline; Diels-Alder-type; Evodiamine; MTT;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.446
