Title :
UV Absorption Spectroscopic Study on the Interaction between Copper(II) Complex [Cu2Cl4(C17H22N2)2] and Bovine Serum Albumin
Author :
Liu, Yu-Fen ; Xia, Hai-Tao ; Rong, De-Fu
Author_Institution :
Sch. of Chem. Eng., Huaihai Inst. of Technol., Lianyungang, China
Abstract :
The binding reaction of the Copper(II) Complex [Cu2C14(C17H22N2)2] with bovine serum albumin (BSA) was studied by UV absorption spectroscopy under the simulative physiological conditions. The binding constants were 6.67×104, 5.61×104 and 3.79×104 L·mol-1 at 291K, 298 K and 305K respectively. The thermodynamic parameters ΔH, ΔS and ΔG were calculated at different temperatures, and the result showed that hydrogen bonds and Van der Waals are two main reactions between Copper(II) Complex and BSA.
Keywords :
bio-optics; biochemistry; copper compounds; hydrogen bonds; molecular biophysics; physiological models; proteins; reaction rate constants; thermodynamics; ultraviolet spectra; van der Waals forces; UV absorption spectroscopy; binding constant; binding reaction; bovine serum albumin; copper complex; hydrogen bonds; simulative physiological condition; thermodynamic parameter; van der Waals forces; Absorption; Bovine; Chemistry; Copper; Hydrogen; Spectroscopy; Thermodynamics; Bovine serum albumin; Cu(II) complex; UV absorption spectrum;
Conference_Titel :
Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on
Conference_Location :
Macau, Macao
Print_ISBN :
978-1-4577-1987-5
DOI :
10.1109/iCBEB.2012.463
