Automated hemodynamic regulation with model predictive control

Author

Aufderheide, Brian ; Rao, Ramesh R. ; Bequette, B. Wayne

Author_Institution

Dept. of Chem. Eng., Rensselaer Polytech. Inst., Troy, NY, USA

fYear

1999

fDate

8-9 Apr 1999

Firstpage

73

Lastpage

74

Abstract

A multiple model adaptive predictive controller is designed to regulate mean arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive drugs. The algorithm uses a multiple model adaptive approach in a model predictive control framework to account for inter- and intra-patient variability and explicitly handle drug rate constraints. The controller is evaluated on canines that were pharmacologically altered to exhibit symptoms of hypertension and depressed cardiac output

Keywords

biocontrol; cardiovascular system; closed loop systems; drug delivery systems; haemodynamics; model reference adaptive control systems; predictive control; pressure control; automated haemodynamic regulation; canines; cardiac output; circulatory model; closed loop simulation; controller design; critical care subjects; depressed cardiac output; drug infusion systems; drug rate constraints; hypertension; inotropic drugs; inter-patient variability; intra-patient variability; mean arterial pressure; model predictive control; multiple model adaptive predictive controller; vasoactive drugs; Adaptive control; Automatic control; Blood pressure; Drugs; Hemodynamics; Hypertension; Predictive control; Predictive models; Pressure control; Programmable control;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1999. Proceedings of the IEEE 25th Annual Northeast

Conference_Location

West Hartford, CT

Print_ISBN

0-7803-5486-9

Type

conf

DOI

10.1109/NEBC.1999.755770

Filename

755770